Effects of GPX3 and GSTA1 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population [post]

2019 unpublished
Several lines of evidence support the fact that the presence of oxidative stress plays an important role in the pathophysiological mechanisms of schizophrenia (SCZ). The glutathione peroxidases (GPXs) and glutathione S-transferases (GSTs) are the major antioxidant enzymes. Polymorphic variants of GPX and GST can affect the antioxidant activities of their encoded enzymes. This study explored the possible associations of the GPX3 and GSTA1 gene polymorphisms and schizophrenia in the Chinese Han
more » ... n the Chinese Han population. Methods: DNA from 316 healthy controls and 303 schizophrenic patients was genotyped for single nucleotide polymorphisms(SNPs) rs736775 in GPX3 and rs3957357 in GSTA1 using a PCR-LDR genotyping assay. The χ2 test compared differences in genetic distributions between the two groups in a case-control study. Results: No significant differences in allelic or genotypic frequencies of GPX3 rs736775 or GSTA1 rs3957357 were detected between cases and controls(GPX3 rs736775: χ2 =0.036, P=0.982 by genotype, χ2=0.020, P=0.888, odds ratio=1.017, 95% confidence interval=0.801-1.292 by allele; GSTA1 rs3957357: χ2 =1.100, P=0.577 by genotype, χ2=0.924, P=0.336, odds ratio=1.176, 95% confidence interval=0.845-1.637 by allele). Conclusions: Our results suggest that GPX3 rs736775 and GSTA1 rs3957357 SNPs are unlikely to be a candidate gene for susceptibility to SCZ in at least Chinese Han population. However, these results should be validated by replication in different populations.
doi:10.21203/rs.2.13319/v1 fatcat:zmw2d4iecfculhy7mifueohfh4