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A panel of docking scaffolds was developed for the known molecular targets of the anticancer agents, thieno [2,3-b]pyridines, in order to glean insight into their mechanism of action. The reported targets are the copper-trafficking antioxidant 1 protein, tyrosyl DNA phosphodiesterase 1, the colchicine binding site in tubulin, adenosine A2A receptor, and, finally, phospholipase C-δ1. According to the panel, the A2A receptor showed the strongest binding, inferring it to be the most plausibledoi:10.3390/molecules22122254 pmid:29258235 fatcat:bk33z27gu5bqlbtojd6wco4bji