Research on genetic databases: duties of rescue and equal respect to all

Ignacio Mastroleo
2020 Journal of Science Humanities and Arts - JOSHA  
The ideal exercise of Castellanos et al. asks IRB members to accept or deny a researchers' request for disclosing genes associated with breast-ovarian cancer, a potential clinically significant finding (CSF), to a subgroup of 1500 research participants of a research database of 300,000 subjects. Here, we defend that researchers are under a rational duty to rescue. However, we also argue that only a decision that equally respects the rights and interests of all participants could be a fair and
more » ... uld be a fair and reasonable decision, compatible with ethics and the rule of law. Consequently, IRB members should not only accept the researchers' request to disclose potential CFS to database participants with breast-ovarian cancer genes but also to advocate for an update in the disclosure policy for all participants of the genetic research database. josha.org Journal of Science, Humanities and Arts JOSHA is a service that helps scholars, researchers, and students discover, use, and build upon a wide range of content March 2020 Abstract The ideal exercise of Castellanos et al. asks IRB members to accept or deny a researchers' request for disclosing genes associated with breast-ovarian cancer, a potential clinically significant finding (CSF), to a subgroup of 1500 research participants of a research database of 300,000 subjects. Here, we defend that researchers are under a rational duty to rescue. However, we also argue that only a decision that equally respects the rights and interests of all participants could be a fair and reasonable decision, compatible with ethics and the rule of law. Consequently, IRB members should not only accept the researchers' request to disclose potential CFS to database participants with breast-ovarian cancer genes but also to advocate for an update in the disclosure policy for all participants of the genetic research database.
doi:10.17160/josha.7.2.650 fatcat:zmvvggtxrjhohdmcbbhwagqexa