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Many reports show evidence of the disruption of central noradrenergic activity in the etiology of schizophrenia. A few studies show positive effects of a specific α 2 -agonist, clonidine, on cognition and on positive and negative symptoms of schizophrenia. In this report, we tried clonidine for the treatment of auditory hallucinations in a patient with schizophrenia who had low compliance with antipsychotic treatment. At the end of seven days, auditory hallucinations decreased dramatically.doi:10.14744/dajpns.2019.00037 fatcat:albng33zmfcdlksr7y2izvuxym