We validated the use of a novel image-based method for partial volume correction (PVC), structural-functional synergistic resolution recovery (SFS-RR) for the accurate quantification of dopamine synthesis capacity measured using [ 18 F]DOPA positron emission tomography. The bias and reliability of SFS-RR were compared with the geometric transfer matrix (GTM) method. Both methodologies were applied to the parametric maps of [ 18 F]DOPA utilization rates (k i cer ). Validation was first performed

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... by measuring repeatability on test-retest scans. The precision of the methodologies instead was quantified using simulated [ 18 F]DOPA images. The sensitivity to the misspecification of the full-width-half-maximum (FWHM) of the scanner point-spread-function on both approaches was also assessed. In the in-vivo data, the k i cer was significantly increased by application of both PVC procedures while the reliability remained high (intraclass correlation coefficients 40.85). The variability was not significantly affected by either PVC approach (o10% variability in both cases). The corrected k i cer was significantly influenced by the FWHM applied in both the acquired and simulated data. This study shows that SFS-RR can effectively correct for partial volume effects to a comparable degree to GTM but with the added advantage that it enables voxelwise analyses, and that the FWHM used can affect the PVC result indicating the importance of accurately calibrating the FWHM used in the recovery model.