Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

Hiroshi NONAKA, Qi AN, Fuminori SUGIHARA, Tomohiro DOURA, Akira TSUCHIYA, Yoshichika YOSHIOKA, Shinsuke SANDO
2015 Analytical Sciences  
Herein, we report on a new 19 F MRI probe for the detection and imaging of H2O2. Our designed 2-fluorophenylboronic acid-based 19 F probe promptly reacted with H2O2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying 19 F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H2O2 by 19 F chemical-shift-selective MRI.
doi:10.2116/analsci.31.331 pmid:25864678 fatcat:kmka7cwyuvcgnk6j22g2cx3clq