Vitamin D Toxicity in A Pediatric Toxicological Referral Center: A Cross-Sectional Study from Iran [post]

Fariba Farnaghi, Hossein Hassanian-Moghaddam, Nasim Zamani, Narges Gholami, Latif Gachkar, Maryam Hosseini Yazdi
2020 unpublished
Background: Vitamin D is an essential element for body health whose supplements are generally administered to prevent vitamin D deficiency. Since these supplements are available at homes, vitamin D toxicity may happen in children.Methods: All children younger than 12 years who presented to the pediatric emergency department of Loghman Hakim Hospital, Tehran, Iran with history of ingestion ofvitamin D supplements more than 1500 IU/day were enrolled. Patients' demographic data, on-presentation
more » ... on-presentation signs and symptoms, laboratory findings, treatments given, and outcome were evaluated.Result: Fifteenpatients presented during the study period. Their mean age was 46.53 ±10.14 months and 12 (80%) were girls. All of them had unintentionally ingested vitamin D. Mean ingested dose was 406700.7±227400.1 IU. In eight patients (53.3%), 25 Hydroxyvitamin D level was more than 100 ng/mL. One patient experienced hypercalcemia while all of them were asymptomatic and discharged without complications. There was no significant difference between patients with and without high levels of 25 OH vitamin D regarding lab tests, toxicity course, and outcome.Conclusion: It seems that acute vitamin D toxicity is a benign condition in our pediatric population which may be due to high prevalence of vitamin D deficiency in Iran.
doi:10.21203/rs.3.rs-24130/v1 fatcat:y22tz5vftvhi3cg4wgiolb3bny