Preclinical Lipid profile studies of a classical Ayurvedic preparation "Kutajarista" after chronic administration to male Sprague-Dawley rats

Kaniz Fatema
2014 IOSR Journal of Pharmacy and Biological Sciences  
Kutajarista (KTJ) is an Ayurvedic preparation used as a traditional medicine in the South Asian countries for the treatment of diarrhoea, dysentery and irritable bowel syndrome. The effect of chronic administration of KTJ on the serum lipid profile was studied in this experiment. After 28 days of chronic administration of the KTJ preparation to the male Sprague-Dawley rats at a dose of 40 ml/kg the following biochemical changes were noted. There was a statistically very highly significant
more » ... y significant (p=0.001) increase in serum LDL-C level whereas a significant increase was noted in case of total cholesterol (TC) level (p=0.013). A significant (p=0.039) decrease was noticed in HDL-C level but in case of Non-HDL-C level, a highly significant (p=0.002) increase was noticed. Besides, a statistically very highly significant (p=0.001) decrease was noted in case of serum triglyceride (TG) and VLDL-C level; thus leading to a statistically highly significant increase (p=0.004) in
doi:10.9790/3008-09454650 fatcat:6t34pa4o3faqnnaj22lqln4lz4