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Phytochemical study of the ethanolic extract of Scrophularia syriaca Benth. was attained by chromatographic and spectroscopic procedures, which resulted in the isolation of eight compounds; 6-O-α-Lrhamnopyranosylcatalpol (1), scropolioside B (2), gmelinoside-L (3), 8-acetyl harpagide (4), scropolioside D (5), scropolioside D2 (6) , quercetin (7) and kaempferol-3-O-rutinoside (8). Their antiprotozoal activity was evaluated against Trypanosoma brucei brucei (s427-WT), Trypanosoma brucei bruceidoi:10.25135/rnp.19.03.1224 fatcat:uauoqi7dvvgeno3c5qa4hec7yi