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Cep55 overexpression promotes genomic instability and tumorigenesis in mice
[article]
2019
biorxiv/medrxiv
pre-print
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal role in vivo tumorigenesis remains elusive. Here, using a ubiquitously overexpressing transgenic mouse model, we show that Cep55 overexpression causes spontaneous tumorigenesis and accelerates Trp53+/- induced tumours in vivo. At the cellular
doi:10.1101/780775
fatcat:b6asgy63hvhndflmjvq3chibfm