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A toxicokinetic model was proposed to describe the in vivo dynamics of 14C-fenvalerate applied topically to a susceptible (S) and a pyrethroid resistant (R) strains of the German cockroach. Values of various kinetic parameters, such as cuticular penetration (k1), rub-off (k2), degradation (k3), binding (k4) and excretion (k5), were estimated by computer simulation. The result showed that the penetration and rub-off rates were slower in the R strain than in the S strain. No significantdoi:10.1584/jpestics.18.3_271 fatcat:luzxvvioljgrtorxl6aueog23i