FORMULATION AND EVALUATION OF IN-SITU GEL FORMING OPHTHALMIC DRUG DELIVERY SYSTEM CONTAINING ATROPINE SULPHATE

Eby George, Nirmala College of Pharmacy, Muvattupuzha, Kerala, India, Chinju M Sivaraman, Nirmala College of Pharmacy, Muvattupuzha, Kerala, India
2020 Indian Research Journal of Pharmacy and Science  
In-situ gelling systems are systems of undergoing rapid sol to gel transformation by the external stimulas such as pH, temperature etc. The main aim of the present study is to formulate and evaluate the pH triggered in popularly used drug for mydriatic, cycloplegic, antispasmodic etc. In the present work we have considered the cycloplegic effect of atropine. Due to the rapid wash out and dilution it will de drug when used as eyedrops. In the current work we prepared three formulations with
more » ... mulations with different polymers like sodium alginate, carbopol, HPMC, polyacrlyic acid etc. These sustained release can be obtained from the formulation. The formulations ability, compatibility, viscosity etc. This in delivery when compared with other systems. are systems which are actually solutions or suspensions and they are capable of undergoing rapid sol to gel transformation by the external stimulas such as pH, temperature etc. The main aim of present study is to formulate and evaluate the pH triggered in-situ gel for ophthalmic drug delivery. Atropine is a popularly used drug for mydriatic, cycloplegic, antispasmodic etc. In the present work we have considered the . Due to the rapid wash out and dilution it will de-limits the therapeutic beneficts of drug when used as eyedrops. In the current work we prepared three formulations with different polymers like sodium alginate, carbopol, HPMC, polyacrlyic acid etc. These polymers enhance the viscosity of formulation so that sustained release can be obtained from the formulation. The formulations were evaluated for clarity, pH, gelling ability, compatibility, viscosity etc. This in-situ gel system can be a valuable development for ophthalmic drug delivery when compared with other systems. SITU GEL FORMING OPHTHALMIC DRUG DELIVERY solutions or suspensions and they are capable of undergoing rapid sol to gel transformation by the external stimulas such as pH, temperature etc. The main aim of situ gel for ophthalmic drug delivery. Atropine is a popularly used drug for mydriatic, cycloplegic, antispasmodic etc. In the present work we have considered the s the therapeutic beneficts of drug when used as eyedrops. In the current work we prepared three formulations with different polymers like polymers enhance the viscosity of formulation so that evaluated for clarity, pH, gelling ment for ophthalmic drug
doi:10.21276/irjps.2020.7.2.23 fatcat:463ccgxdu5a5ddl65wdwdfibpi