Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine

Jatinder Katyal, Vikas Sarangal, Yogendra Kumar Gupta
2012 Indian journal of experimental biology  
Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater
more » ... , greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
pmid:22279941 fatcat:zluyyjmjcjcfjgwql44sivcmui