An Angiotensin Converting Enzyme Inhibitor, Benazepril Can Be Transformed to an Active Metabolite, Benazeprilat, by the Liver of Dogs with Ascitic Pulmonary Heartworm Disease

Hitoshi KITAGAWA, Yasunori OHBA, Yasuhito KUWAHARA, Rieko OHNE, Masahiro KONDO, Masakazu NAKANO, Yoshihide SASAKI, Katsuya KITOH
2003 Journal of Veterinary Medical Science  
To examine whether an angiotensin converting enzyme (ACE) inhibitor, benazepril, can be transformed to the active metabolite, benazeprilat, by severely injured liver of dogs with ascitic heartworm disease, benazepril hydrochloride was administered orally to dogs once daily for 7 consecutive days at a dose rate of 0.29 mg/kg to 0.63 mg/kg of body weight, and plasma benazepril and benazeprilat concentrations were determined on the 1st and 7th administration days. In 7 dogs with ascitic pulmonary
more » ... ascitic pulmonary heartworm disease, plasma benazeprilat concentrations tended to be higher than in 7 control dogs both on the 1st and 7th administration days. The peak concentration and area under the concentration-time curve tended to be greater in dogs of the ascites group than in control dogs, but the statistics could not detect significant differences in the time to peak concentration and t 1/2 between the control and ascites groups. Plasma ACE activities decreased after administration of benazepril. In dogs with ascitic heartworm disease, benazepril was readily transformed to benazeprilat by the liver, and was effective for suppression of plasma ACE activity.
doi:10.1292/jvms.65.701 pmid:12867730 fatcat:zcsgj7lcffb2vmq6sjakp2cub4