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Author response: RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro
Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from S-adenosyl-L-methionine to N 6 amino group of adenosine bases in RNA (m 6 A) and DNA (m 6 dA). Emerging evidence highlights a role of METTL3-METTL14 in the chromatin context, especially in processes where DNA and RNA are held in close proximity. However, a mechanistic framework about specificity for substrate RNA/DNA and their interrelationship remain unclear. By systematically studying methylation activity anddoi:10.7554/elife.67150.sa2 fatcat:ed76ypsz2bhxba43zlpqpob6wy