Multi-omics Study Reveal AP-1 as a Regulation Hub in Inflammation Induced Hyperalgesia Rat [post]

Xiang Zhu, Feng Li, Miqun Wang, Huibin Su, Xuedong Wu, Haiyan Qiu, Wang Zhou, Chunli Shan, Cancan Wang, Lei Wei
2020 unpublished
Inflammation associated chronic pain is a global clinical problem, affecting millions of people worldwide. However, the underlying mechanism of inflammation associated chronic pain remains unclear. Complete Freund's adjuvant (CFA) induced cutaneous inflammation rat has been widely used as an inflammation-induced pain hypersensitivity model. Herein, we presented a transcriptomic profile of CFA-induced rat dorsal root ganglion via a multi-omics approach. We identified 418 differentially expressed
more » ... rentially expressed mRNAs, 120 differentially expressed microRNAs and 2670 differentially methylated regions, which are all highly associated with multiple inflammation related pathways, including NF-κB signaling pathways and IFN signaling pathways. Multi-omics analysis further demonstrated that AP-1 network, which works as a regulator of inflammation response, is sophisticatedly regulated at both transcriptomic and epigenetic level. We believe our data will not only provide drug screening targets for treating chronic pain and inflammation, but also shed a light on the molecular network inflammation induced hyperalgesia.
doi:10.21203/rs.3.rs-48553/v1 fatcat:m7zi377j45hivksij72vnu2qyu