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Protein Kinase C Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells
2003
Diabetes
Insulin resistance as well as pancreatic -cell failure can be induced by elevated free fatty acid (FFA) levels. We studied the mechanisms of FFA-induced apoptosis in rat and human -cells. Chronic treatment with high physiological levels of saturated fatty acids (palmitate and stearate), but not with monounsaturated (palmitoleate and oleate) or polyunsaturated fatty acids (linoleate), triggers apoptosis in ϳ20% of cultured RIN1046-38 cells. Apoptosis restricted to saturated FFAs was also
doi:10.2337/diabetes.52.4.991
pmid:12663471
fatcat:tzfg5fcabzgf7key4rq3bw2mlq