Suppression of behavioral activity and hippocampal adrenaline caused by surgical stress in type 2 diabetes model mice [post]

2019 unpublished
In these days, the occurrence of neuropsychological complications during perioperative period has become the subject of discussion. Diabetes is indicated as one of the metabolic risk factors. Although the number of patients with diabetes mellitus (DM) has been increasing, the pathophysiology of postoperative neuropsychological dysfunction in DM patient is still unclear. Recently, a deficiency of neurotransmitters, such as monoamines, was reported to be associated with mental disorders.
more » ... disorders. Therefore, we investigated the effects of surgical stress on behavioral activity and the hippocampal noradrenaline (NA) level in type 2 diabetes mellitus model (T2DM) mice.Methods Eighty-four 6-week-old male C57BL/6J mice were divided into four groups (control, surgery control, Animal Experiment Committee (approved on 23th/October/2017, No. P151004).
doi:10.21203/rs.2.16726/v1 fatcat:zutp7d6uvjbgdgnn4zahday7vy