Multi-gram Preparation of 7-Nitroquinoxalin-2-amine

Daniel do Amaral, Fernando de Sá Alves, Eliezer Barreiro, Stefan Laufer, Lídia Lima
2017 Journal of the Brazilian Chemical Society  
Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good
more » ... procedure in good yields and high purity without further purification such as crystallization or column chromatography.
doi:10.21577/0103-5053.20170018 fatcat:lql4gaoxvzf6pdshok7buglcx4