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Metabolism of a New Antiplatelet Agent, Ethyl 2-(4, 5-bis (4-methoxyphenyl) thiazol-2-yl) pyrrol-1-ylacetate (KBT-3022), in Rats, Mice, Dogs and Humans
Drug Metabolism and Pharmacokinetics
The metabolism of a new antiplatelet agent, ethyl 2-[4,5-bis (4-methoxyphenyl) thiazol-2-yl] pyrrol-1-ylacetate (KBT 3022), was studied in rats, mice, dogs and humans. We found 12 metabolites (M1-M12) after oral administration of KBT 3022 in rat's feces and bile, and identified M3, M5, M6 and M9. After KBT-3022 was hydrolyzed to M9, the demethylation of the methoxyphenyl groups in 4-or/and 5 positions of thiazol ring of M9 resulted in the formation of M3, M5, M6. Furtheremore, these metabolitesdoi:10.2133/dmpk.12.130 fatcat:75ra3fdfv5dqbgf2bqmthqeoh4