MORPHOLOGICAL STUDY OF NOCICEPTIVE NEURONS IN THE TRIGEMINAL GANGLION

Sankaran Pk, Sivanandan Dajah
2016 International Journal of Health and Rehabilitation Sciences  
The trigeminal ganglion neurons are responsible for migraine and trigeminal neuralgia so it is important to study the morphology of neurons responsible for nociception. The rats' trigeminal ganglion were collected and stained for crystal violet and immunohistochemical localization for GFAP and CGRP to study the morphology of cells responsible for nociception. The pseudo unipolar neurons were classified into small (<22micron), medium (22-29 micron) and large (>29 micron) based on their size. The
more » ... on their size. The CGRP was localized in cytoplasm on neurons especially in small neurons with dense staining indicating those neurons are responsible for nociception. The GFAP was localized in satellite glial cells surrounding each neuron. Upregulation of GFAP and CGRP can lead to pathological conditions like migraine and trigeminal neuralgia.
doi:10.5455/ijhrs.000000098 fatcat:sjnbbyzugnf5fmwd7vq3xlngby