One-pot Green Synthesis for Pyrimido[4,5-d]pyrimidine Derivatives

Mazaahir Kidwai, Kavita Singhal, Shuchi Kukreja
2007 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
Water has been used efficiently as a solvent for the reaction of barbituric acid, aldehyde and urea or thiourea to yield pyrimido[4,5-d]pyrimidines. This environmentally benign procedure leads to high yields of products of greater purity in a single step using water.
doi:10.1515/znb-2007-0518 fatcat:rk274hsoxzfqfiolnwi5n7jhea