SNARE proteins and membrane fusion

Zia Choudhry, Azadeh A Rikani, Adnan Maqsood Choudhry, Sadaf Tariq, Fozia Zakaria, Muhammad Waheed Asghar, Muhammad Khan Sarfraz, Numan Majeed, Huma Ikram, Nusrat Jahan Mobassarah
2013 El Mednifico Journal  
Diverse proteins catalyze membrane fusion reactions. These mediate recognition of the membranes for fusion and pull the membranes close together to destabilize the lipid/water interface and to initiate mixing of the lipids. In the nervous system, membrane fusion is vital for neuroexocytosis, neuro transmitter release and chemical synaptic transmission. Three neuronal soluble NSF (N-ethyl-maleimide-sensitive fusion protein) attachment receptor (SNARE) proteins exist, namely: (i) vesicle
more » ... i) vesicle associated membrane protein (VAMP-2), also called synaptobrevin; (ii) 25 kDa synaptosome-associated protein (SNAP-25); and (iii) syntaxin 1A (STX1). The SNAREs are involved in the neuronal membrane fusion process. (El Med J 2:1; 2014)
doi:10.18035/emj.v2i1.52 fatcat:6g4yycpafjc2pfkamcm7adeppy