Controlled delivery systems of cellulose matrix for oxytetracycline: In vitro dissolution

Disha Mishra, Puja Khare, K. Shanker, Dhananjay K.Singh, Suaib Luqman
2016 European Journal of Molecular and Clinical Medicine  
Microfibrillated cellulose (MFC) has recently been explored as a novel nanostructured system for controlled drug delivery. The present study examines the releasing behavior and antibacterial efficacy of cellulose (CC) and tempo-oxidized-microfibrillated cellulose (TO-MFC) loaded with oxytetracycline at three different physiological pH (2.1, 6.8 and 9.0). The releasing mechanism from cellulosic matrix was assessed by applying zero order, first order, and second order & Ritger-Peppas model. The
more » ... Peppas model. The well diffusion assay was carried out to investigate the antibacterial efficacy of the prepared MFCs. Results indicate that the stability for the drug loaded on TO-MFC at all the pH was significant. TO-MFC and CC both showed sustained release of OTC and followed Ritger-Peppas model signifying the diffusion process. The sustained antibacterial activities of these cellulosic matrixes were also observed. Results indicate that both drug delivery systems retained their medicinal properties against bacteria. The application of MFC could be very promising since it allows a sustained release of drug conserving long-term antibacterial efficiency. Focal points: Microfibrillated cellulose (MFC) loaded with oxytetracycline at three different physiological pH (2.1, 6.8 and 9.0) was examined. The OTC and RO-MFC drug delivery system was stable at all pH. Riteger-peppas model was favourable for the drug release phenomenon signifying the diffusion process. The antibacterial activities of three matrixes appear in the similar manner as reported for releasing.
doi:10.1016/j.nhtm.2016.06.001 fatcat:ggn6kmiw5zaqdekoyzwwzmaeiu