Animal Models of Obsessive-Compulsive Disorder: Strain Differences

Taimon P. Maio, Guilherme B. Filgueiras, Daniel C. Cunha, Celio Estanislau
2014 World Journal of Neuroscience  
Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.) and compulsions (repetitive, stereotyped and perseverant acts). Animal models of OCD are specifically devoted to simulating compulsive features of the disorder. In OCD, compulsive behaviors are recognized as repetitive and maladaptive and symptoms relief can be experienced due to treatment with selective serotonin reuptake inhibitors. Many animal models of OCD are provided with some degree of
more » ... h some degree of validity. Genetically based differences in behavior in animal models of OCD are of great value, given that human OCD is reported to involve genetic factors. Some animal models of OCD were already used in studies for the evaluation of strain differences. These works were explored in the present review.
doi:10.4236/wjns.2014.43027 fatcat:vts55wbeejdg7j5h54gvpjkkfe