A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
ADMET and DMPK
The "anomalous solubility behavior at higher pH values" of several acidic drugs originally studied by Higuchi et al. in 1953 , but hitherto not fully rationalized, has been re-analyzed using a novel solubility-pH analysis computer program, pDISOL-X TM . The program internally derives implicit solubility equations, given a set of proposed equilibria and constants (iteratively refined by weighted nonlinear regression), and does not require explicit Henderson-Hasselbalch equations. Thedoi:10.5599/admet.2.1.30 fatcat:m32oswfk4ja7tpy37z5qba34x4