Review of speckle and phase variance optical coherence tomography to visualize microvascular networks

Mohammad Sultan Mahmud, David W. Cadotte, Barry Vuong, Carry Sun, Timothy W. H. Luk, Adrian Mariampillai, Victor X. D. Yang
2013 Journal of Biomedical Optics  
High-resolution mapping of microvasculature has been applied to diverse body systems, including the retinal and choroidal vasculature, cardiac vasculature, the central nervous system, and various tumor models. Many imaging techniques have been developed to address specific research questions, and each has its own merits and drawbacks. Understanding, optimization, and proper implementation of these imaging techniques can significantly improve the data obtained along the spectrum of unique
more » ... um of unique research projects to obtain diagnostic clinical information. We describe the recently developed algorithms and applications of two general classes of microvascular imaging techniques: speckle-variance and phase-variance optical coherence tomography (OCT). We compare and contrast their performance with Doppler OCT and optical microangiography. In addition, we highlight ongoing work in the development of variance-based techniques to further refine the characterization of microvascular networks. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
doi:10.1117/1.jbo.18.5.050901 pmid:23616094 fatcat:3cjcsnbdnnbczo26ocxpx62p3q