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The most common age-related metabolic bone diseases, osteoporosis, and Paget's disease of bone (PDB) are characterised by osteoclast-mediated increased bone resorption, which is generalised in the former and focal, coupled to increased bone formation, in the latter. For reasons incompletely understood, in ageing, osteoclast differentiation increases, which is associated with hyperactivity and hypersensitivity to RANKL. In studies performed on animal models demonstrated an age-dependentdoi:10.17638/03142532 fatcat:ksfxafbirjdwbkinij6sardvvi