Role of p38 and p62 in age-related bone loss

Jacqueline Lim
The most common age-related metabolic bone diseases, osteoporosis, and Paget's disease of bone (PDB) are characterised by osteoclast-mediated increased bone resorption, which is generalised in the former and focal, coupled to increased bone formation, in the latter. For reasons incompletely understood, in ageing, osteoclast differentiation increases, which is associated with hyperactivity and hypersensitivity to RANKL. In studies performed on animal models demonstrated an age-dependent
more » ... stromal/osteoblastic-induced osteoclastogenesis, increased expression of RANKL and M-CSF, as well as decreased expression of OPG in stromal/osteoblastic cells. The latter was also observed in studies performed on human BMSCs. Both p38 and p62 are important in OC differentiation and play a role in autophagy, which typically decreases with ageing, but their role in age-related increased bone resorption is unclear.
doi:10.17638/03142532 fatcat:ksfxafbirjdwbkinij6sardvvi