A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells

Li-Li Lou, Peng Zhao, Zhuo-Yang Cheng, Rui Guo, Guo-Dong Yao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
2018 Figshare  
In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.
doi:10.6084/m9.figshare.5853309 fatcat:p25igkkihbghroirxkbssdr4u4