Determinants of Neurocognitive Impairment in HIV in a Cohort of Patients on Antiretroviral Therapy Followed in Bangui (Central African Republic)

Mbelesso Pascal, Tekpa Gaspard, Ndouongou­-Kouna Philomène, Yangatimbi Emmanuel, Amakade­-Woyengba Phrygie Avilah, Honisse Hortense
2016 Neuroscience & Medicine  
Infection with HIV is one of the deadliest epidemics of our time and its type is widespread in the Central African Republic. It is frequently accompanied by neurological complications. Objective: To contribute to a better understanding of neurocognitive disorders in patients living with HIV (PLHIV) in Bangui, and to identify associated factors using the International HIV Dementia Scale (IHDS) as a screening tool. We conducted a descriptive and analytical crosssectional study from 1 December
more » ... from 1 December 2014 to 30 January 2015, in a cohort of patients seen on one of the supported sites in Bangui. A total of 400 patients were received in followup visit during the study period of which 244 met the inclusion criteria. The prevalence of neurocognitive disorders was 25%, 95% CI [19.70 30.92]. The mean age of subjects was 42.77 ± 9.58 with extremes ranging from 24 64 years. The sex ratio (F/M) was 4.5 in. The average score for different tests was 10.93 ± 1.13 with extremes of 7 and 12. The disorder was more about the gestural sequence. Determinants of neu rocognitive disorders in the cohort were older age and lower educational level (p < 0.05). It is useful to conduct further studies to confirm these results by combining a battery of neuropsycho logical tests to recommend this test for all the support sites of PLHIV in the country.
doi:10.4236/nm.2016.71001 fatcat:cbl72mxc4ne33inzc3myz7rghq