Clinical Utility and Approach to Estimate Postprandial Hypertriglycemia by A Newly Designed Oral Fat-loading Test

Masahiko Igarashi, Akihiko Hirata, Toshiyuki Yamauchi, Hiroshi Yamaguchi, Hiromi Tsuchiya, Hiroshi Ohnuma, Yumi Jimbu, Yoko Okuyama, Toru Shirata, Nobuhiro Otsu, Haru Fukuyama, Sachiko Takahashi (+2 others)
2003 Journal of atherosclerosis and thrombosis  
The objective of this study was to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. Twenty-three healthy normolipidemic volunteers were orally administered a test meal consisting of a mixture of Telmeal 2.0  and 20 g of saltfree butter after fasting for 12 h. To measure the levels of total cholesterol (T-Cho), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), remnant-like particlecholesterol (RLP-C), lipoprotein (a) [Lp (a)], free fatty acid,
more » ... free fatty acid, apolipoproteins (Apos), plasma glucose (PG), immunoreactive insulin (IRI) , and high-sensitivity C-reactive protein (hs-CRP), venous blood samples were collected before the meal and at each hour until 9 h after fat-loading. The levels of both TG and RLP-C were drastically elevated at 2 h after fat-loading and these levels remained high until 4 h ( p < 0.01). A significant correlation between TG and RLP-C was also observed at 2, 3 and 4 h, and the values of the correlation coefficients (r) were 0.837, 0.838, and 0.908, respectively. In contrast, the levels of T-Cho, HDL-C, Lp (a), Apos, PG, and hs-CRP did not change. Furthermore, there were no gastrointestinal symptoms during or after the study. These results strongly suggested that this newly designed fat-loading test was very useful for evaluating postprandial hypertriglycemia, including remnant concentrations. J Atheroscler Thromb, 2003; 10: 314-320.
doi:10.5551/jat.10.314 pmid:14718749 fatcat:gktwiwjzhvexflfsxydzz2vgde