Mechanistic investigations of a bifunctional squaramide organocatalyst in asymmetric Michael reaction and observation of stereoselective retro-Michael reaction

Eszter Varga, László Tamás Mika, Antal Csámpai, Tamás Holczbauer, György Kardos, Tibor Soós
2015 RSC Advances  
The mechanism of cinchona–squaramide organocatalytic Michael addition was studied using in situ IR and NMR experiments. As a result, not only kinetic parameters were determined but a stereoselective retro-Michael reaction was also observed.
doi:10.1039/c5ra19593d fatcat:p5lasuydyvax3pu2ct53cchqxa