The in vitro Antimycobacterial investigation of some basic meta-/para-Alkoxyphenylcarbamic Esters Bearing 4-(4-Fluoro/2-methoxyphenyl)piperazin-1-yl fragment

Ivan Malik, Eva Sedlarova, Jozef Csollei, Lukas Stanzel, Lubica Sichrovska, Jirina Stolarikova
2014 Dhaka University Journal of Pharmaceutical Sciences  
Following our previous systematic research with ortho-/meta-/para-alkoxyphenylcarbamic acid esters as antimycobacterially active compounds, the set of the derivatives containing meta-/paraalkoxyphenylcarbamoyloxy and 4-(4-fluorophenyl/2-methoxyphenyl)piperazin-1-yl moieties were tested for their in vitro activity against Mycobacterium tuberculosis CNCTC My 331/88 as well as against potential pathogenic strains of M. kansasii CNCTC My 235/80, M. avium CNCTC My 330/88 and M. kansasii 6 509/96 by
more » ... nsasii 6 509/96 by applying the micromethod for the determination of the minimum inhibitory concentration (MIC). In terms of estimated MIC readouts, the advantage of the molecules under study has been the activity against Mycobacterium tuberculosis.
doi:10.3329/dujps.v12i2.17621 fatcat:am4orekajvbcnhytud6kqnvpma