Unfortunate Result of Vaccination

Z. B. ADAMS
1876 Boston Medical and Surgical Journal  
On the 1st of October, 1876, a package of ivory points, charged with fresh cow matter, was procured of reputable vaccine purveyors, and used as follows : -Three children were inoculated, namely : No. 1. A healthy boy twenty months old, of healthy Irish parents; a first vaccination. No. 2. A pale, rather large infant, whose mother is consumptive ; age, one year; of Irish parents ; a first vaccination. No. 3. A healthy infant four months old, born of Irish parents. In these, and in all the cases
more » ... d in all the cases cited, the matter was carried without delay from where it was got to the arm in which it was placed. The rest of the points in this package were given to a neighboring physician, who used them without effect. No result occurring in any of the children inoculated with the points in this package, on October 21st a similar package of fresh cow matter was procured from the same parties. This package was used and distributed in the same manner as the first, and the result, so far as known, was null, except in cases No. 1 and No. 2. In No. 1, on the seventh day, three dry scabs wore found upon the points of inoculation, and the skin around showed a scaly epidermis, indicating a short-lived hypersemia or slight inflammation. In No. 2 there was a little redness of the skin on the third and fourth days, at the seat of inoculation, which, however, had entirely disappeared on the seventh day. I am thus particular in stating these facts, as it is possible, although not probable, that the previous attempts at vaccination may have some bearing upon the unfortunate result of the third trial. A package of human matter, warranted pure and fresh vaccine virus, was now procured from the same parties as before, with which were inoculated Nos. 1, 2, and 3, each in three places on the arm at about tho insertion of the deltoid. The remainder of the package was thrown into the fire. The result was as follows : on the seventh day No. 1 presented three very perfect-looking vaccine vesicles, of the ordinary size and shape, round, cupped, with a thin scab just forming in the centre, surrounded by a pellucid ring of pure lymph, with slight areolas of
doi:10.1056/nejm187612210952502 fatcat:ohw4om2ipjbk7hrbommbigy5wa