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Pruritus is a diagnostic hallmark for Lichen Simplex Chronicus (LSC). It elicits a scratch response, initiating the itch-scratch cycle, which in turn aggravates the inflammatory response and exacerbates the disease severity. Treating this symptom can be challenging The purpose of this study is to distinguish which type of pruritus has a leading role in the pathogenesis of LSC by studying changes skin barrier functions and evaluating patients psychopathology. We compare the results from thedoi:10.14748/ssm.v48i2.1572 fatcat:i6v7r445yng6tchtpkd52bigfe