A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa

Meng Li, Xiaolan Wang, Xiaoke Zheng, Jianchao Wang, Wei Zhao, Kai Song, Xuan Zhao, Yanli Zhang, Haixue Kuang, Weisheng Feng
2015 Molecules  
A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.
doi:10.3390/molecules200815192 pmid:26307955 fatcat:jtziib7tg5gcvh3i6q3xf66d2m