The Expression of Solute carrier family members Genes in Mouse Ovarian Developments

Lee-Gyun O, Chang-Eun Park
2017 Korean Journal of Clinical Laboratory Science  
생쥐의 난소 발달과정에서 Solute carrier family 유전자들의 발현양상 오이균 1 , 박창은 2 1 가톨릭대학교 성빈센트병원 진단검사의학과, 2 남서울대학교 임상병리학과 분자진단연구소 Granulosa cells, which surround the oocyte within the ovarian follicle, play an essential role in creating conditions required for the development of oocytes and follicles. The solute carrier family (SLC) is comprised of influx transporters of steroidal hormones, various drugs, and several other substrates. The differential expression of selected DEGs was confirmed using in situ
more » ... ing in situ hybridization analysis. SLC23A3 and SLC39A10 were highly expressed in the ovary. The SLC39A10 gene was expressed in the primordial follicle stage, but SLC23A3 was expressed in the growing follicle stage. Contrastingly, the expression of SLC23A3 was increased in granulosa cells at the growing follicle stage. The differential expressions of SLC23A3 and SLC39A10 between the primordial and primary follicles were additionally confirmed by using follicle isolations. The gene expression profile from the present study may provide insight for future studies on the mechanism(s) involved in primordial-primary follicular transition and suggestions to promote follicular development in ovarian dysfunction.
doi:10.15324/kjcls.2017.49.1.40 fatcat:63dc6nvpxvcj5jja4b7pym5q7u