Degradation kinetics and characterization of degradation products of losartan potassium by LC-MS/MS method
Kinetika degradacije i karakterizacija degradacionih proizvoda losartan kalijuma LC-MS/MS metodom

Vladimir Dobričić, Bojan Marković
2019 Arhiv za farmaciju  
This paper presents study of losartan potassium stability evaluation by liquid chromatography with UV/VIS and MS-MS detection and its degradation profile. A solution of losartan potassium was exposed to the following stress agents: 0.1 M HCl, 0.1 M NaOH, and 3% (v/v) H 2 O 2 . The analyses of losartan potassium solutions were carried out in a gradient elution mode with acetonitrile and 0.1% (v/v) CF 3 COOH aqueous solution and constant flow rate of 0.5 mL min -1 within 22 min run time. After 7
more » ... run time. After 7 days of losartan potassium solutions exposure to the stress agents at room temperature, it was found that the degree of degradation in the presence of 0.1 M HCl and 0.1 M NaOH was less than 1%, while in the presence of 3% H 2 O 2 degradation was significantly higher (about 10%). Chemical structure elucidation of the major degradation products of losartan potassium was performed using LC-MS/MS method. The concentration versus time plot indicated that in 3% (v/v) H 2 O 2 solution losartan potassium was degraded according to the pseudo zero-order reaction kinetics with 1.48ꞏ10 -8 mol L -1 day -1 rate constant.
doi:10.5937/arhfarm1902080x fatcat:mz5v4umaajcm7averhf36b2mi4