The Effect of Hormonal Superovulatory Preparation FSH on the Levels of Catecholamines in the Blood Plasma of Sheep

B Sto R O V A, A Ra
1996 Physiol. Res   unpublished
R e c e iv e d M a rch < 5, 1995 A c c e p te d N o v e m b e r 13, 1995 Summary The effect of hormonal stimulation with FSH injection in the doses of 18 mg (360 IU) and 24 mg (480 IU FSH) on the levels of plasma catecholamines (dopamine, norepinephrine and epinephrine) was studied by radioenzymatic methods during synchronized oestrous cycles of the sheep. Catecholamines were determined in the blood plasma before and 24, 48, 96 and 120 hours after application of FSH. It follows from the results
more » ... ws from the results that the levels of plasma dopamine increased significantly (p<0.001) 24 and 48 hours after FSH application. Furthermore, the levels of dopamine (D A) during the other time intervals observed, compared with those of controls before hormonal stimulation, remained at a higher level. A lower dose of the hormone (18 mg) had a more pronounced effect on changes in the levels of plasma dopamine. Norepinephrine (NE) did not exhibit any significant changes in comparison with the plasma levels of dopamine in the sheep after hormonal stimulation with FSH. A statistically significant increase in plasma norepinephrine was recorded 24 hours after administration of 18 or 24 mg FSH. During the other time intervals observed, its levels did not differ from the control values. Plasma epinephrine (E) showed a significant increase 24 and 48 hours after FSH application but not later. The effect of FSH on plasma catecholamine levels was not dose-dependent and their increase was pronounced especially in the period of ovulation.