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SYNOPSIS The presentation of coeliac disease is changing, and typical malabsorption is now uncommon. Patients are more likely to present with non-specific symptoms or with iron and/or folate deficiency. The diagnosis still depends upon finding villous atrophy in the small intestine by endoscopic biopsy of the distal duodenum. The mucosal changes should improve after the patient has followed a gluten-free diet for at least six months. IgA antibodies to gliadin, endomysium and/or tissuedoi:10.18773/austprescr.2001.036 fatcat:l5f65ogi4rd4neeyehciudvcce