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An assay of platelet monoamine oxidase type-B (MAO-B) activity has been explored in the search for a reliable method of discriminating selegiline (SG) use from methamphetamine (MA) abuse. MAO-B activity was measured by fluorimetry of 4-hydroxyquinoline (4HOQ) produced by oxidative deamination of kynuramine, the substrate for MAO-B. MA and most of its related compounds including its precursors produced no platelet MAO-B inhibition in vitro even at their lethal levels, though SG, its specificdoi:10.1248/jhs.49.189 fatcat:xs5xprsp75fqnmds2vtehhcfnu