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Neurodegenerative Diseases - Molecular Mechanisms and Current Therapeutic Approaches [Working Title]
Addiction is a chronically relapsing disorder characterized by a compulsion to seek and take a substance of abuse, the development of dependence, and a negative emotional state when intake is stopped. Compelling evidence argues that dysregulation of the brain stress system is a key constituent of the addiction process. Through mechanisms of negative reinforcement, the stress system is posited to induce negative emotional state referred to as the 'dark side of addiction' as it becomes thedoi:10.5772/intechopen.93152 fatcat:7hkgopo6izcqpfrnef3iu7lxsm