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Comparative analysis between salmeterol xinafoate (SX) powders was carried out to define quantitatively the solid-state and surface particle properties relevant to formulation of these materials into dry powder respiratory drug delivery systems. SX powders were prepared in supercritical CO 2 using a single-step crystallization process (Solution Enhanced Dispersion by Supercritical f luids, SEDS™), the volume mean diameter and deagglomeration behaviour of pure drug compound were optimised fordoi:10.14356/kona.2002020 fatcat:ibpopey2j5bwnn24hppkqyaviy