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The evaluation of the concentrations of methylprednisolone applied intravenously and by iontophoresis in the pig
2009
Acta Veterinaria
The current clinical research on pharmacokinetics of methylprednisolone was performed on male pigs to whom was administered either intravenously or locally, via iontophoresis. Equal doses of methylprednisolone sodium succinate (MPSS) were applied, i.e. 40 mg it total per animal. In all pigs artificial inflammation of knee and elbow joints was provoked four days prior to the treatment. Four hours after the application of methylprednisolone tissue samples (both synovial fluid and hyaline
doi:10.2298/avb0903157d
fatcat:q4ge3zxlzfg5pfmpdx5z2dp2h4