An investigation on the experimental ethylene glycol toxication and its therapy in dogs Suınmary: Ethylene glycol (EG) has been using widely as antifree:::e, when taken accidentally or given experimentally it causes toxication. In this study, antifreeze was given to the six experimental dogs as 13 ml/kg body weight by an oesophagus tube. The main symptoms seen wirhin six hours were tachycardia, tachypnea and ataxie. Incoordination and depression were the other symptoms observed. One oj the dogs

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... ed. One oj the dogs was alloted as control (i.e., not treated), and one dog was initial1y treated at 12. ho ur and three dogs were initial1y treated at ı5. hour and one dog was initial1y treated at 24. hour after they were given EG. The treatment coıısisted of IV injectioııs of 5.5 ml of 20 % ethanol and 8 ml oj 5 % sodium bicarbonat per kilogram oj body weight. AJter the inilial treatment, Jive additional treatments were given wit/ı Jourhour intervals between doses. In each dog, blood calciu/11, blood urea nitrogene (BVN) were determined immediately prior to the oral administration oj EG and 1, 2, 3, 4, 6 and 8 hours aJter giying it. Blood calcium values at the Jirst and second hours were significantly (p <0.05) increased wi/h a subseı Doç.