Child maltreatment and neglect is a significant social problem. Present work addresses the important issue of quantifying the vulnerability to child maltreatment and neglect, proposing the application in the Italian context of a new General Index on Vulnerability to Maltreatment and Neglect to achieve a more comprehensive understanding of this phenomenon. Methods: The paper presents the first findings of the vulnerability among Italian minors, obtained through the new General Index, based on a

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... et of 65 indicators that already existed at the regional and national levels. Results: The General Index summarizes both the weaknesses of territory in terms of risk factors and its ability to react according to the policies and public services. A global index could be useful for allocating resources and monitoring progress. To understand and ensure the effectiveness of preventive interventions, it is essential to build both an overall picture at the national and regional levels. Conclusion: This new index could give policymakers information on where to direct their efforts to prevent child maltreatment.