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Modelling interaction sites in protein domains with interaction profile hidden Markov models
Motivation: Due to the growing number of completely sequenced genomes, functional annotation of proteins becomes a more and more important issue. Here, we describe a method for the prediction of sites within protein domains, which are part of protein-ligand interactions. As recently demonstrated, these sites are not trivial to detect because of a varying degree of conservation of their location and type within a domain family. Results: The developed method for the prediction of protein-liganddoi:10.1093/bioinformatics/btl486 pmid:17000753 fatcat:7hpozzhswba2tmpysnieawrmiy