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NBRL has reported that the bleeding time is affected by temperature, the hematocrit, the platelet count, the platelet size, the platelet function, and the plasma clotting proteins: von Willebrand factor (vWF), factor VIII, and fibrinogen levels . Figure 1. The relation of bleeding time to shed blood for all patients. Reprinted, with permission, from Am J Clin Pathol 1997;108:579-584 Valeri CR (2018) The therapeutic effectiveness and safety of universal donor group O frozen RBC, group Odoi:10.15761/tec.1000173 fatcat:v7lj3ho3avbkjig22m6g2h3vxi