Field Desorption Mass Spectra of Gastrine Peptides and Glutathione Derivatives

Michael Przybylski, Ingo Lüderwald, Ekkehard Kraas, Wolfgang Voelter, Sidney D. Nelson
1979 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
Oligopeptides comprising the sequence of the C-terminal tetrapeptide of gastrine, Trp-Met-Asp-Phe-NH2, and several derivatives of glutathione, γ-Glu-Cys(SR)-Gly, were characterized by field desorption mass spectrometry. The field desorption mass spectra obtained at various field ion emitter temperatures reveal abundant molecular ions and fragmentation reactions that yield partial sequence information. In the series of glutathione derivatives investigated, characteristic ions formed by cleavage
more » ... formed by cleavage of the γ-Glu-Cys peptide bond determine the substituent at the Cys residue and can therefore be used to identify corresponding conjugation products of drug metabolites with glutathione.
doi:10.1515/znb-1979-0518 fatcat:vffby5g6hzbztla7j6qibgzaie