Effect of Pterostilbene on cardiac oxidative stress on high-fat diet-fed and Streptozotocin-induced type 2 diabetic mice

Gunaseelan Thangasamy, Leelavinothan Pari, Paari Ellappan, Kannan Duraisamy
2019 Asian Journal of Pharmacy and Pharmacology  
Objective: Diabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in high-fat diet-fed and streptozotocin-induced type 2 diabetic mice. The experimental study period was 16 weeks. Material and methods: C57BL6/J mice were fed a normal diet, normal diet with Pterostilbene (PTS), high-fat diet (HFD) and streptozotocin injection (10 week only), diabetic mice
more » ... ly), diabetic mice with PTS for last 6 weeks. Diabetic mice had high level of cardiac total th cholesterol, triglycerides and free fatty acids level. Cardiac markers such as AST, CK-MB Results and conclusion: and LDH levels were significantly increased in diabetic mice. The activity level of enzymic (SOD, CAT and GPx) and non-enzymic antioxidant (Vitamin C, E and GSH) were lower diabetic mice. The levels of lipid peroxidation markers significantly increased in heart tissues. Treatment with PTS at a dose of 40mg/Kg BW significantly improved the parameters. This study suggests that PTS could be effective in improving cardiac dyslipidemia and antioxidant status in type 2 diabetes.
doi:10.31024/ajpp.2019.5.4.25 fatcat:yzwqbghb6jabrp6khog63hwhra