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Objective: Diabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in high-fat diet-fed and streptozotocin-induced type 2 diabetic mice. The experimental study period was 16 weeks. Material and methods: C57BL6/J mice were fed a normal diet, normal diet with Pterostilbene (PTS), high-fat diet (HFD) and streptozotocin injection (10 week only), diabetic micedoi:10.31024/ajpp.2019.5.4.25 fatcat:yzwqbghb6jabrp6khog63hwhra